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Development History The foundational work on IGF-1 LR3 emerged from pharmaceutical research in the 1990s aimed at developing IGF-1 analogs with improved pharmacological properties

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However, some studies propose a biphasic effect of iron status on OA progression, where iron overload and deficiency increase OA risk (Kennish et al., 2014)

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4 From mechanisms to applications: translational considerations for TME-oriented nanoplatforms The strategies discussed in previous sections are grounded in mechanistic insights and preclinical models